SCOPe 2.05: Domain d4xi3c_: 4xi3 C:

Lineage for d4xi3c_ (4xi3 C:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (61 PDB entries)
   Uniprot P03372 307-551

8. Domain d4xi3c_: 4xi3 C: [280508]
   automated match to d2qxsb_
   complexed with 29s

Details for d4xi3c_

PDB Entry: 4xi3, 2.49 Å

PDB Description: estrogen receptor alpha ligand binding domain in complex with bazedoxifene

PDB Compounds: (C:) Estrogen receptor

SCOPe Domain Sequences for d4xi3c_:

Sequence, based on SEQRES records:

>d4xi3c_ a.123.1.1 (C:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld

Sequence, based on observed residues (ATOM records):

>d4xi3c_ a.123.1.1 (C:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvyttlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld

Timeline for d4xi3c_:

• d4xi3c_ is new in SCOPe 2.05-stable
  
• d4xi3c_ appears in SCOPe 2.06
  
• d4xi3c_ appears in the current release, SCOPe 2.08