SCOPe 2.06: Domain d4xg8a_: 4xg8 A:

Lineage for d4xg8a_ (4xg8 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (60 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d4xg8a_: 4xg8 A: [280183]
   automated match to d3tuca_
   complexed with x8g

Details for d4xg8a_

PDB Entry: 4xg8, 2.4 Å

PDB Description: crystal structure of an inhibitor-bound syk

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4xg8a_:

Sequence, based on SEQRES records:

>d4xg8a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
drklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaeanvmq
qldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyl
eesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecin
yykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlm
nlcwtydvenrpgfaavelrlrnyyydvvn

Sequence, based on observed residues (ATOM records):

>d4xg8a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
drklltledkelgsggtvkkgyyqmvvktvavkildpalkdellaeanvmqqldnpyivr
migiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvhrd
laarnvllvtqhyakisdfglskalradenyykaqthpvkwyapecinyykfssksdvws
fgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydvenrp
gfaavelrlrnyyydvvn

Timeline for d4xg8a_:

• d4xg8a_ first appeared in SCOPe 2.05
  
• d4xg8a_ appears in SCOPe 2.07
  
• d4xg8a_ appears in the current release, SCOPe 2.08