SCOPe 2.08: Domain d5em6a_: 5em6 A:

Lineage for d5em6a_ (5em6 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5em6a_: 5em6 A: [280157]
   automated match to d4li5a_
   complexed with 5q3, so4; mutant

Details for d5em6a_

PDB Entry: 5em6, 2.78 Å

PDB Description: egfr kinase domain mutant "tmlr" with pyridone compound 19: 4-[(2- azanylpyrimidin-4-yl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]- 2-oxidanylidene-1~{h}-pyridine-3-carboxamide

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5em6a_:

Sequence, based on SEQRES records:

>d5em6a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d5em6a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriyth
qsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmi
dadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyeedmddvvdadeyli
p

Timeline for d5em6a_:

• d5em6a_ first appeared in SCOPe 2.05
  
• d5em6a_ appears in SCOPe 2.07