SCOPe 2.08: Domain d5ew3b_: 5ew3 B:

Lineage for d5ew3b_ (5ew3 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (30 PDB entries)

8. Domain d5ew3b_: 5ew3 B: [279929]
   automated match to d4agca_
   complexed with 5t2

Details for d5ew3b_

PDB Entry: 5ew3, 2.5 Å

PDB Description: human vascular endothelial growth factor receptor 2 (kdr) kinase domain in complex with aal993

PDB Compounds: (B:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d5ew3b_:

Sequence, based on SEQRES records:

>d5ew3b_ d.144.1.7 (B:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathseh
ralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpyk
vapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgl
ardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgv
kideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq

Sequence, based on observed residues (ATOM records):

>d5ew3b_ d.144.1.7 (B:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplggqvieadafgidktatcrtvavkmlkegathsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykdflt
lehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifd
rvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtm
ldcwhgepsqrptfselvehlgnllq

Timeline for d5ew3b_:

• d5ew3b_ first appeared in SCOPe 2.05
  
• d5ew3b_ appears in SCOPe 2.07