SCOPe 2.05: Domain d4yvxa_: 4yvx A:

Lineage for d4yvxa_ (4yvx A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (40 PDB entries)
   Uniprot P42330

8. Domain d4yvxa_: 4yvx A: [279661]
   automated match to d2fgba_
   complexed with gmr, nap

Details for d4yvxa_

PDB Entry: 4yvx, 2.3 Å

PDB Description: crystal structure of akr1c3 complexed with glimepiride

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d4yvxa_:

Sequence; same for both SEQRES and ATOM records:

>d4yvxa_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsfashpnypys

Timeline for d4yvxa_:

• d4yvxa_ is new in SCOPe 2.05-stable
  
• d4yvxa_ appears in SCOPe 2.06
  
• d4yvxa_ appears in the current release, SCOPe 2.08