SCOPe 2.05: Domain d4xzlx_: 4xzl X:

Lineage for d4xzlx_ (4xzl X:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (119 PDB entries)
   Uniprot P15121

8. Domain d4xzlx_: 4xzl X: [279515]
   automated match to d1zuax_
   complexed with edo, f49, nap

Details for d4xzlx_

PDB Entry: 4xzl, 1.7 Å

PDB Description: crystal structure of human akr1b10 complexed with nadp+ and jf0049

PDB Compounds: (X:) Aldo-keto reductase family 1 member B10

SCOPe Domain Sequences for d4xzlx_:

Sequence; same for both SEQRES and ATOM records:

>d4xzlx_ c.1.7.1 (X:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
matfvelstkakmpivglgtwksplgkvkeavkvaidagyrhidcayvyqnehevgeaiq
ekiqekavkredlfivsklwptfferplvrkafektlkdlklsyldvylihwpqgfksgd
dlfprddkgnaiggkatfldaweameelvdeglvkalgvsnfshfqiekllnkpglkykp
vtnqvechpyltqekliqychskgitvtaysplgspdrpwakpedpslledpkikeiaak
hkktaaqvlirfhiqrnvivipksvtpariveniqvfdfklsdeematilsfnrnwracn
llqsshledypfnaey

Timeline for d4xzlx_:

• d4xzlx_ is new in SCOPe 2.05-stable
  
• d4xzlx_ appears in SCOPe 2.06
  
• d4xzlx_ appears in the current release, SCOPe 2.08