SCOPe 2.07: Domain d4x21b_: 4x21 B:

Lineage for d4x21b_ (4x21 B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (42 PDB entries)

8. Domain d4x21b_: 4x21 B: [279379]
   automated match to d3py3a_
   complexed with 3wh, cl

Details for d4x21b_

PDB Entry: 4x21, 1.95 Å

PDB Description: the map kinase jnk3 as target for halogen bonding

PDB Compounds: (B:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d4x21b_:

Sequence, based on SEQRES records:

>d4x21b_ d.144.1.7 (B:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
qfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqthak
rayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvvt
ryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpef
mkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpak
risvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmn

Sequence, based on observed residues (ATOM records):

>d4x21b_ d.144.1.7 (B:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
qfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqthak
rayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglavtryyrapevilgmg
ykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyve
nrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyi
nvwydpaeveapppqiderehtieewkeliykevmn

Timeline for d4x21b_:

• d4x21b_ first appeared in SCOPe 2.05
  
• d4x21b_ appears in SCOPe 2.06
  
• d4x21b_ appears in the current release, SCOPe 2.08