SCOPe 2.05: Domain d5c8ma_: 5c8m A:

Lineage for d5c8ma_ (5c8m A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (65 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5c8ma_: 5c8m A: [278541]
   automated match to d4li5a_
   complexed with 4yw; mutant

Details for d5c8ma_

PDB Entry: 5c8m, 2.9 Å

PDB Description: egfr kinase domain mutant "tmlr" with compound 17

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5c8ma_:

Sequence, based on SEQRES records:

>d5c8ma_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d5c8ma_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelatspkanke
ildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyeedmddvvdadeyl
ip

Timeline for d5c8ma_:

• d5c8ma_ is new in SCOPe 2.05-stable
  
• d5c8ma_ appears in SCOPe 2.06
  
• d5c8ma_ appears in the current release, SCOPe 2.08