SCOPe 2.08: Domain d5cepa_: 5cep A:

Lineage for d5cepa_ (5cep A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5cepa_: 5cep A: [278051]
   automated match to d2j7ta_
   complexed with 50e

Details for d5cepa_

PDB Entry: 5cep, 1.99 Å

PDB Description: dlk in complex with inhibitor n-(1-isopropyl-5-(piperidin-4-yl)-1h- pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine

PDB Compounds: (A:) Mitogen-activated protein kinase kinase kinase 12

SCOPe Domain Sequences for d5cepa_:

Sequence, based on SEQRES records:

>d5cepa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lwevpfeeildlqwvgsgaqgavflgrfhgeevavkkvrdlketdikhlrklkhpniitf
kgvctqapcycilmefcaqgqlyevlragrpvtpsllvdwsmgiaggmnylhlhkiihrd
lkspnmlityddvvkisdfgtskelsdkstkmsfagtvawmapevirnepvsekvdiwsf
gvvlwelltgeipykdvdssaiiwgvgsnslhlpvpsscpdgfkillrqcwnskprnrps
frqillhldiasadvlstpqetyfksqaewreevklhfekik

Sequence, based on observed residues (ATOM records):

>d5cepa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lwevpfeeildlqwvgsgaqgavflgrfhgeevavkkvrdlketdikhlrklkhpniitf
kgvctqapcycilmefcaqgqlyevlragrpvtpsllvdwsmgiaggmnylhlhkiihrd
lkspnmlityddvvkisdfgfagtvawmapevirnepvsekvdiwsfgvvlwelltgeip
ykdvdssaiiwgvgsnslhlpvpsscpdgfkillrqcwnskprnrpsfrqillhldiasa
dvlstpqetyfksqaewreevklhfekik

Timeline for d5cepa_:

• d5cepa_ first appeared in SCOPe 2.05
  
• d5cepa_ appears in SCOPe 2.07