SCOPe 2.08: Domain d5aava1: 5aav A:307-551

Lineage for d5aava1 (5aav A:307-551)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (171 PDB entries)

8. Domain d5aava1: 5aav A:307-551 [278005]
   Other proteins in same PDB: d5aava2
   automated match to d3erta_
   complexed with gw5

Details for d5aava1

PDB Entry: 5aav, 1.95 Å

PDB Description: optimization of a novel binding motif to to (e)-3-(3,5- difluoro-4-((1r,3r)-2-(2-fluoro-2-methylpropyl)-3-methyl-2, 3,4,9-tetrahydro-1h-pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (azd9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d5aava1:

Sequence, based on SEQRES records:

>d5aava1 a.123.1.1 (A:307-551) automated matches {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda
hrlha

Sequence, based on observed residues (ATOM records):

>d5aava1 a.123.1.1 (A:307-551) automated matches {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvytfeekdhihrvldkitdtlihlmakagltlqq
qhqrlaqlllilshirhmsnkgmehlysmvvpsydlllemldahrlha

Timeline for d5aava1:

• d5aava1 first appeared in SCOPe 2.05, called d5aava_
  
• d5aava1 appears in SCOPe 2.07