Lineage for d4x6ia_ (4x6i A:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2533756Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2533757Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2533758Family d.3.1.1: Papain-like [54002] (26 proteins)
  6. 2533784Protein (Pro)cathepsin K [54028] (3 species)
  7. 2533785Species Human (Homo sapiens) [TaxId:9606] [54029] (56 PDB entries)
    Uniprot P43235 116-329 ! Uniprot P43235 115-329
  8. 2533820Domain d4x6ia_: 4x6i A: [277615]
    automated match to d1tu6a_
    complexed with 3y1, so4

Details for d4x6ia_

PDB Entry: 4x6i (more details), 1.87 Å

PDB Description: development of n-(functionalized benzoyl)-homocycloleucyl- glycinonitriles as potent cathepsin k inhibitors.
PDB Compounds: (A:) cathepsin k

SCOPe Domain Sequences for d4x6ia_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4x6ia_ d.3.1.1 (A:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

SCOPe Domain Coordinates for d4x6ia_:

Click to download the PDB-style file with coordinates for d4x6ia_.
(The format of our PDB-style files is described here.)

Timeline for d4x6ia_: