SCOPe 2.07: Domain d4qp7b_: 4qp7 B:

Lineage for d4qp7b_ (4qp7 B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56135] (69 PDB entries)

8. Domain d4qp7b_: 4qp7 B: [277301]
   automated match to d3sa0a_
   complexed with 363

Details for d4qp7b_

PDB Entry: 4qp7, 2.25 Å

PDB Description: crystal structure of erk2 in complex with 2-(1h-pyrazol-4-yl)-5h- pyrrolo[2,3-b]pyrazine

PDB Compounds: (B:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4qp7b_:

Sequence, based on SEQRES records:

>d4qp7b_ d.144.1.7 (B:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d4qp7b_ d.144.1.7 (B:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvaeyvatrwyrapeimlns
kgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarn
yllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsde
piaeapfkfdmelddlpkeklkelifeetarfqpg

Timeline for d4qp7b_:

• d4qp7b_ first appeared in SCOPe 2.05
  
• d4qp7b_ appears in SCOPe 2.06
  
• d4qp7b_ appears in the current release, SCOPe 2.08