SCOPe 2.06: Domain d4qpaa_: 4qpa A:

Lineage for d4qpaa_ (4qpa A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56135] (31 PDB entries)

8. Domain d4qpaa_: 4qpa A: [277291]
   automated match to d3sa0a_
   complexed with 35w

Details for d4qpaa_

PDB Entry: 4qpa, 2.85 Å

PDB Description: crystal structure of erk2 in complex with 7-(1-benzyl-1h-pyrazol-4- yl)-2-(pyridin-4-yl)-5h-pyrrolo[2,3-b]pyrazine

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4qpaa_:

Sequence, based on SEQRES records:

>d4qpaa_ d.144.1.7 (A:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d4qpaa_ d.144.1.7 (A:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlreiki
llrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqil
rglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhlteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspinlkarnyll
slphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdepia
eapfkfdmelddlpkeklkelifeetarfqpg

Timeline for d4qpaa_:

• d4qpaa_ first appeared in SCOPe 2.05
  
• d4qpaa_ appears in SCOPe 2.07
  
• d4qpaa_ appears in the current release, SCOPe 2.08