SCOPe 2.07: Domain d4xj0b_: 4xj0 B:

Lineage for d4xj0b_ (4xj0 B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56135] (69 PDB entries)

8. Domain d4xj0b_: 4xj0 B: [277036]
   automated match to d1erka_
   complexed with 41b

Details for d4xj0b_

PDB Entry: 4xj0, 2.58 Å

PDB Description: crystal structure of erk2 in complex with an inhibitor 14k

PDB Compounds: (B:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4xj0b_:

Sequence, based on SEQRES records:

>d4xj0b_ d.144.1.7 (B:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d4xj0b_ d.144.1.7 (B:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
karnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyyd
psdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Timeline for d4xj0b_:

• d4xj0b_ first appeared in SCOPe 2.05
  
• d4xj0b_ appears in SCOPe 2.06
  
• d4xj0b_ appears in the current release, SCOPe 2.08