SCOPe 2.08: Domain d4x1ga_: 4x1g A:

Lineage for d4x1ga_ (4x1g A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (32 PDB entries)

8. Domain d4x1ga_: 4x1g A: [277017]
   automated match to d1m13a_
   complexed with 3wf, 3wg, ipa, mpd

Details for d4x1ga_

PDB Entry: 4x1g, 2.25 Å

PDB Description: crystal structure of the hpxr-lbd in complex with the synthetic estrogen 17alpha-ethinylestradiol and the pesticide trans-nonachlor

PDB Compounds: (A:) Nuclear receptor subfamily 1 group I member 2

SCOPe Domain Sequences for d4x1ga_:

Sequence, based on SEQRES records:

>d4x1ga_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitgs

Sequence, based on observed residues (ATOM records):

>d4x1ga_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvsreeaakwsqvrkdlcslkvslql
rgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisl
lkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqlllepmlkfhymlkklql
heeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkima
mltelrsinaqhtqrllriqdihpfatplmqelfgitgs

Timeline for d4x1ga_:

• d4x1ga_ first appeared in SCOPe 2.05
  
• d4x1ga_ appears in SCOPe 2.07