Lineage for d4x6ja_ (4x6j A:)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2154579Family d.3.1.1: Papain-like [54002] (26 protein domains)
  6. 2154605Protein (Pro)cathepsin K [54028] (3 species)
  7. 2154606Species Human (Homo sapiens) [TaxId:9606] [54029] (51 PDB entries)
    Uniprot P43235 116-329 ! Uniprot P43235 115-329
  8. 2154625Domain d4x6ja_: 4x6j A: [276779]
    automated match to d1tu6a_
    complexed with 3y2, cl, gol, k, pgo

Details for d4x6ja_

PDB Entry: 4x6j (more details), 1.59 Å

PDB Description: development of n-(functionalized benzoyl)-homocycloleucyl- glycinonitriles as potent cathepsin k inhibitors.
PDB Compounds: (A:) cathepsin k

SCOPe Domain Sequences for d4x6ja_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4x6ja_ d.3.1.1 (A:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4x6ja_:

Click to download the PDB-style file with coordinates for d4x6ja_.
(The format of our PDB-style files is described here.)

Timeline for d4x6ja_: