SCOPe 2.08: Domain d5bvfa_: 5bvf A:

Lineage for d5bvfa_ (5bvf A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56135] (74 PDB entries)

8. Domain d5bvfa_: 5bvf A: [276655]
   automated match to d1erka_
   complexed with 4vj, so4

Details for d5bvfa_

PDB Entry: 5bvf, 1.9 Å

PDB Description: tetrahydropyrrolo-diazepenones as inhibitors of erk2 kinase

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d5bvfa_:

Sequence, based on SEQRES records:

>d5bvfa_ d.144.1.7 (A:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
agpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrt
lreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicy
flyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyv
atrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgsps
qedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqal
ahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy

Sequence, based on observed residues (ATOM records):

>d5bvfa_ d.144.1.7 (A:) MAP kinase Erk2 {Human (Homo sapiens) [TaxId: 9606]}
agpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrt
lreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicy
flyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvrwyrapeimtksidi
wsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarnyllslphkn
kvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdepiaeapfkf
dmelddlpkeklkelifeetarfqpgy

Timeline for d5bvfa_:

• d5bvfa_ first appeared in SCOPe 2.05
  
• d5bvfa_ appears in SCOPe 2.07