SCOPe 2.08: Domain d4u74b_: 4u74 B:

Lineage for d4u74b_ (4u74 B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein automated matches [190585] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187592] (52 PDB entries)

8. Domain d4u74b_: 4u74 B: [276577]
   automated match to d2d0tb_
   complexed with hem, nhe, pim; mutant

Details for d4u74b_

PDB Entry: 4u74, 2.31 Å

PDB Description: crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (g262a mutant)

PDB Compounds: (B:) Indoleamine 2,3-dioxygenase 1

SCOPe Domain Sequences for d4u74b_:

Sequence, based on SEQRES records:

>d4u74b_ a.266.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefagasagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsed
pskleakgtggtdlmnflktvrstteksllkeg

Sequence, based on observed residues (ATOM records):

>d4u74b_ a.266.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
iskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefagasagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflk
tvrstteksllkeg

Timeline for d4u74b_:

• d4u74b_ first appeared in SCOPe 2.05
  
• d4u74b_ appears in SCOPe 2.07