Lineage for d4xjsa_ (4xjs A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2101600Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
    3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
  4. 2103986Superfamily c.23.14: N-(deoxy)ribosyltransferase-like [52309] (4 families) (S)
    there are similar active site architectures as well as the catalytic mechanisms of functionally characterised members
  5. 2104030Family c.23.14.3: ADP ribosyl cyclase-like [56630] (3 protein domains)
    contains extra N-terminal all-alpha subdomain
    automatically mapped to Pfam PF02267
  6. 2104031Protein ADP ribosyl cyclase [56631] (4 species)
  7. 2104056Species Human (Homo sapiens) [TaxId:9606] [159490] (42 PDB entries)
    Uniprot P28907 45-291
  8. 2104137Domain d4xjsa_: 4xjs A: [276385]
    automated match to d1zvmc_
    complexed with 733, hsx

Details for d4xjsa_

PDB Entry: 4xjs (more details), 2.8 Å

PDB Description: human cd38 complexed with inhibitor 1 [6-fluoro-2-methyl-4-[(2,3,6- trichlorobenzyl)amino]quinoline-8-carboxamide]
PDB Compounds: (A:) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

SCOPe Domain Sequences for d4xjsa_:

Sequence, based on SEQRES records: (download)

>d4xjsa_ c.23.14.3 (A:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefat
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
evhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkfl
qcv

Sequence, based on observed residues (ATOM records): (download)

>d4xjsa_ c.23.14.3 (A:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefat
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
evhnlqpekvqtleawvihgsrdlcqdptikelesiiskrniqfsckniyrpdkflqcv

SCOPe Domain Coordinates for d4xjsa_:

Click to download the PDB-style file with coordinates for d4xjsa_.
(The format of our PDB-style files is described here.)

Timeline for d4xjsa_: