SCOPe 2.08: Domain d4xjsa_: 4xjs A:

Lineage for d4xjsa_ (4xjs A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
   3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

4. Superfamily c.23.14: N-(deoxy)ribosyltransferase-like [52309] (4 families)
   there are similar active site architectures as well as the catalytic mechanisms of functionally characterised members

5. Family c.23.14.3: ADP ribosyl cyclase-like [56630] (3 proteins)
   contains extra N-terminal all-alpha subdomain
   automatically mapped to Pfam PF02267

6. Protein ADP ribosyl cyclase [56631] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159490] (46 PDB entries)
   Uniprot P28907 45-291

8. Domain d4xjsa_: 4xjs A: [276385]
   automated match to d1zvmc_
   complexed with 733, hsx

Details for d4xjsa_

PDB Entry: 4xjs, 2.8 Å

PDB Description: human cd38 complexed with inhibitor 1 [6-fluoro-2-methyl-4-[(2,3,6- trichlorobenzyl)amino]quinoline-8-carboxamide]

PDB Compounds: (A:) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

SCOPe Domain Sequences for d4xjsa_:

Sequence, based on SEQRES records:

>d4xjsa_ c.23.14.3 (A:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefat
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
evhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkfl
qcv

Sequence, based on observed residues (ATOM records):

>d4xjsa_ c.23.14.3 (A:) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefat
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
evhnlqpekvqtleawvihgsrdlcqdptikelesiiskrniqfsckniyrpdkflqcv

Timeline for d4xjsa_:

• d4xjsa_ first appeared in SCOPe 2.05
  
• d4xjsa_ appears in SCOPe 2.07