SCOPe 2.07: Domain d5ac0a_: 5ac0 A:

Lineage for d5ac0a_ (5ac0 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.82: ALDH-like [53719] (1 superfamily)
   consists of two similar domains with 3 layers (a/b/a) each; duplication
   core: parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.82.1: ALDH-like [53720] (3 families)
   binds NAD differently from other NAD(P)-dependent oxidoreductases

5. Family c.82.1.1: ALDH-like [53721] (6 proteins)

6. Protein Aldehyde reductase (dehydrogenase), ALDH [53722] (9 species)

7. Species Sheep (Ovis aries) [TaxId:9940] [53727] (3 PDB entries)

8. Domain d5ac0a_: 5ac0 A: [276262]
   automated match to d1bxsa_
   complexed with k9p, mg, nad

Details for d5ac0a_

PDB Entry: 5ac0, 1.9 Å

PDB Description: ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog

PDB Compounds: (A:) Retinal dehydrogenase 1

SCOPe Domain Sequences for d5ac0a_:

Sequence; same for both SEQRES and ATOM records:

>d5ac0a_ c.82.1.1 (A:) Aldehyde reductase (dehydrogenase), ALDH {Sheep (Ovis aries) [TaxId: 9940]}
dvpapltnlqfkytkifinnewhssvsgkkfpvfnpateeklceveegdkedvdkavkaa
rqafqigspwrtmdasergrllnkladlierdrlllatmeamnggklfsnaylmdlggci
ktlrycagwadkiqgrtipmdgnfftytrsepvgvcgqiipwnfpllmflwkigpalscg
ntvvvkpaeqtpltalhmgslikeagfppgvvnivpgygptagaaisshmdvdkvaftgs
tevgklikeaagksnlkrvslelggkspcivfadadldnavefahqgvfyhqgqcciaas
rlfveesiydefvrrsverakkyvlgnpltpgvsqgpqidkeqyekildliesgkkegak
lecgggpwgnkgyfiqptvfsdvtddmriakeeifgpvqqimkfkslddvikranntfyg
lsagiftndidkaitvssalqsgtvwvncysvvsaqcpfggfkmsgngrelgeygfheyt
evktvtikisqkns

Timeline for d5ac0a_:

• d5ac0a_ first appeared in SCOPe 2.05
  
• d5ac0a_ appears in SCOPe 2.06
  
• d5ac0a_ appears in the current release, SCOPe 2.08