SCOPe 2.08: Domain d4zlob_: 4zlo B:

Lineage for d4zlob_ (4zlo B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein pak1 [56146] (1 species)
   OPK group; PAK/STE20 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56147] (19 PDB entries)

8. Domain d4zlob_: 4zlo B: [275797]
   automated match to d3q4za_
   complexed with 4pv, gol

Details for d4zlob_

PDB Entry: 4zlo, 2.5 Å

PDB Description: serine/threonine-protein kinase pak1 complexed with a dibenzodiazepine: identification of an allosteric site on pak1

PDB Compounds: (B:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4zlob_:

Sequence, based on SEQRES records:

>d4zlob_ d.144.1.7 (B:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
ileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpkkeli
ineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcre
clqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtpywma
pevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsa
ifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatkn

Sequence, based on observed residues (ATOM records):

>d4zlob_ d.144.1.7 (B:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
ileklrsivsvkkkytrfekigqvytamgqevaikqmeliineilvmrenknpnivnyld
syvvmeylaggsltdvvtetcmdegqiaavcreclqaleflhsnqvihrdiksdnillgm
dgsvkltdfgfcaqitpeqskrstmvgtpywmapevvtrkaygpkvdiwslgimaiemie
geppylnenplralyliatngtpelqnpeklsaifrdflnrclemdvekrgsakellqhq
flkiakplssltpliaaakeatkn

Timeline for d4zlob_:

• d4zlob_ first appeared in SCOPe 2.05
  
• d4zlob_ appears in SCOPe 2.07