SCOPe 2.05: Domain d4zpea_: 4zpe A:

Lineage for d4zpea_ (4zpe A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (258 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4zpea_: 4zpe A: [275791]
   automated match to d1tqfa_
   complexed with 4qa

Details for d4zpea_

PDB Entry: 4zpe, 1.7 Å

PDB Description: bace1 in complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3- isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4zpea_:

Sequence, based on SEQRES records:

>d4zpea_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgawagelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d4zpea_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgawagelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgvggsmiiggidhslytgslw
ytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksik
aasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpv
esqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsacdefrtaavegpfvt
ldmedcgyn

Timeline for d4zpea_:

• d4zpea_ is new in SCOPe 2.05-stable
  
• d4zpea_ appears in SCOPe 2.06
  
• d4zpea_ appears in the current release, SCOPe 2.08