Lineage for d4ywya_ (4ywy A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2125386Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
    core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
  4. 2126724Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families) (S)
    core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
  5. 2127146Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
    part of Pfam PF04389
  6. 2127147Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
    Glutaminyl cyclase
  7. 2127148Species Human (Homo sapiens) [TaxId:9606] [142534] (22 PDB entries)
    Uniprot Q16769 33-361
  8. 2127188Domain d4ywya_: 4ywy A: [275755]
    automated match to d2zema_
    complexed with cl, edo, pbd, so4, zn; mutant

Details for d4ywya_

PDB Entry: 4ywy (more details), 1.95 Å

PDB Description: crystal structure of double mutant y115e y117e human glutaminyl cyclase in complex with inhibitor pbd-150
PDB Compounds: (A:) Glutaminyl-peptide cyclotransferase

SCOPe Domain Sequences for d4ywya_:

Sequence, based on SEQRES records: (download)

>d4ywya_ c.56.5.8 (A:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqdsly
gsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqai
ehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmdd
neenldestidnlnkilqvfvleylhl

Sequence, based on observed residues (ATOM records): (download)

>d4ywya_ c.56.5.8 (A:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
awpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhimqr
iqrlqadwvleidtflsqtpegersfsniistlnptakrhlvlachydskyfshwnnrvf
vgatdsavpcammlelaraldkkllslktvsdspdlslqliffdgeeaflhwspqdslyg
srhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaie
helhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddn
eenldestidnlnkilqvfvleylhl

SCOPe Domain Coordinates for d4ywya_:

Click to download the PDB-style file with coordinates for d4ywya_.
(The format of our PDB-style files is described here.)

Timeline for d4ywya_: