SCOPe 2.08: Domain d5a46a_: 5a46 A:

Lineage for d5a46a_ (5a46 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d5a46a_: 5a46 A: [275543]
   automated match to d3gqla_
   complexed with 38o, edo, so4

Details for d5a46a_

PDB Entry: 5a46, 2.63 Å

PDB Description: fgfr1 in complex with dovitinib

PDB Compounds: (A:) fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b

SCOPe Domain Sequences for d5a46a_:

Sequence, based on SEQRES records:

>d5a46a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgegcfgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgley
cynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfg
lardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypg
vpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn
qey

Sequence, based on observed residues (ATOM records):

>d5a46a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgegcfgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppglee
qlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardidyykk
ttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeg
hrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqey

Timeline for d5a46a_:

• d5a46a_ first appeared in SCOPe 2.05
  
• d5a46a_ appears in SCOPe 2.07