SCOPe 2.08: Domain d4wxhb2: 4wxh B:99-352

Lineage for d4wxhb2 (4wxh B:99-352)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.12: Plant O-methyltransferase, C-terminal domain [64111] (6 proteins)
   automatically mapped to Pfam PF00891

6. Protein Carminomycin 4-O-methyltransferase [110660] (1 species)

7. Species Streptomyces peucetius [TaxId:1950] [110661] (6 PDB entries)
   Uniprot Q06528

8. Domain d4wxhb2: 4wxh B:99-352 [275479]
   Other proteins in same PDB: d4wxha1, d4wxhb1
   automated match to d1tw2b2
   complexed with 3vl, dtu, sah, so4

Details for d4wxhb2

PDB Entry: 4wxh, 1.9 Å

PDB Description: carminomycin-4-o-methyltransferase (dnrk) variant (298ser insert) in complex with s-adenosyl-l-homocysteine (sah) and aclacinomycin t

PDB Compounds: (B:) Carminomycin 4-O-methyltransferase DnrK

SCOPe Domain Sequences for d4wxhb2:

Sequence, based on SEQRES records:

>d4wxhb2 c.66.1.12 (B:99-352) Carminomycin 4-O-methyltransferase {Streptomyces peucetius [TaxId: 1950]}
paaqrawhdltqavaradisftrlpdairtgrptyesiygkpfyedlagrpdlrasfdsl
lacdqdvafdapaaaydwtnvrhvldvgggkggfaaaiarraphvsatvlemagtvdtar
sylkdeglsdrvdvvegdffeplprkadaiilsfvllnwpdhdavriltrcaealepggr
iliherddlhensfneqfsteldlrmlvflggalrtrekwdglaasaglvveevrqlpsp
tipydlsllvlapa

Sequence, based on observed residues (ATOM records):

>d4wxhb2 c.66.1.12 (B:99-352) Carminomycin 4-O-methyltransferase {Streptomyces peucetius [TaxId: 1950]}
paaqrawhdltqavaradisftrlpdairtgrptyesiygkpfyedlagrpdlrasfdsl
lacdqdvafdapaaaydwtnvrhvldvgggkggfaaaiarraphvsatvlemagtvdtar
sylkdeglsdrvdvvegdffeplprkadaiilsfvllnwpdhdavriltrcaealepggr
iliherddlensfneqfsteldlrmlvflggalrtrekwdglaasaglvveevrqlpspt
ipydlsllvlapa

Timeline for d4wxhb2:

• d4wxhb2 first appeared in SCOPe 2.05
  
• d4wxhb2 appears in SCOPe 2.07