Lineage for d4zyca_ (4zyc A:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2321461Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  4. 2321462Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families) (S)
    binds to the transactivation domain of human p53
  5. 2321463Family a.42.1.1: SWIB/MDM2 domain [47593] (5 protein domains)
    Pfam PF02201
  6. 2321470Protein MDM2 [47594] (2 species)
  7. 2321488Species Human (Homo sapiens) [TaxId:9606] [47596] (60 PDB entries)
  8. 2321559Domain d4zyca_: 4zyc A: [275315]
    automated match to d3jzra_
    complexed with 4ss, so4

Details for d4zyca_

PDB Entry: 4zyc (more details), 1.95 Å

PDB Description: discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-mdm2 interaction with a distinct binding mode: hdm2 (mdm2) complexed with cpd5
PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d4zyca_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4zyca_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
etlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycsndllgd
lfgvpsfsvkehrkiytmiyrnlv

SCOPe Domain Coordinates for d4zyca_:

Click to download the PDB-style file with coordinates for d4zyca_.
(The format of our PDB-style files is described here.)

Timeline for d4zyca_: