SCOPe 2.07: Domain d4tyha_: 4tyh A:

Lineage for d4tyha_ (4tyh A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (16 PDB entries)

8. Domain d4tyha_: 4tyh A: [275232]
   Other proteins in same PDB: d4tyhb_
   automated match to d1kwpa_
   complexed with 39g

Details for d4tyha_

PDB Entry: 4tyh, 3 Å

PDB Description: ternary complex of p38 and mk2 with a p38 inhibitor

PDB Compounds: (A:) MAP kinase-activated protein kinase 2

SCOPe Domain Sequences for d4tyha_:

Sequence, based on SEQRES records:

>d4tyha_ d.144.1.7 (A:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
glqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwr
asqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksi
geaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyv
apevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpe
wsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwe
dvkeemtsalatmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Sequence, based on observed residues (ATOM records):

>d4tyha_ d.144.1.7 (A:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
glqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwr
asqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksi
geaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyv
apevlgpekydkscdmwslgvimyillcgyppfysnhgrmgqyefpnpewsevseevkml
irnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsala
tmrvdyeqikikkiedasnplllkrrkkaraleaaalah

Timeline for d4tyha_:

• d4tyha_ first appeared in SCOPe 2.05
  
• d4tyha_ appears in SCOPe 2.06
  
• d4tyha_ appears in the current release, SCOPe 2.08