SCOPe 2.08: Domain d4zy5b_: 4zy5 B:

Lineage for d4zy5b_ (4zy5 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein pak1 [56146] (1 species)
   OPK group; PAK/STE20 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56147] (19 PDB entries)

8. Domain d4zy5b_: 4zy5 B: [274665]
   automated match to d3q4za_
   complexed with 4t5, dms, so4

Details for d4zy5b_

PDB Entry: 4zy5, 2.35 Å

PDB Description: crystal structure of p21-activated kinase 1 in complex with an inhibitor compound 17

PDB Compounds: (B:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4zy5b_:

Sequence, based on SEQRES records:

>d4zy5b_ d.144.1.7 (B:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
eklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpkkeliin
eilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcrecl
qaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtpywmape
vvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaif
rdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatk

Sequence, based on observed residues (ATOM records):

>d4zy5b_ d.144.1.7 (B:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
eklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqpkkeliine
ilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcreclq
aleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtpywmapev
vtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifr
dflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatk

Timeline for d4zy5b_:

• d4zy5b_ first appeared in SCOPe 2.05
  
• d4zy5b_ appears in SCOPe 2.07