SCOPe 2.06: Domain d4zjjd_: 4zjj D:

Lineage for d4zjjd_ (4zjj D:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein pak1 [56146] (1 species)
   OPK group; PAK/STE20 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56147] (19 PDB entries)

8. Domain d4zjjd_: 4zjj D: [274410]
   automated match to d3q4za_
   complexed with 4or, mg

Details for d4zjjd_

PDB Entry: 4zjj, 2.2 Å

PDB Description: pak1 in complex with (s)-n-(tert-butyl)-3-((2-chloro-5-ethyl-8-fluoro- dibenzodiazepin-11-yl)amino)pyrrolidine-1-carboxamide

PDB Compounds: (D:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4zjjd_:

Sequence, based on SEQRES records:

>d4zjjd_ d.144.1.7 (D:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
eileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpkkel
iineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcr
eclqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtpywm
apevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpekls
aifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeat

Sequence, based on observed residues (ATOM records):

>d4zjjd_ d.144.1.7 (D:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
eileklrsivsvkkkytrfekigqgasgtvytamdvevaikqmnlpkkeliineilvmre
nknpnivnyldsygdelwvvmeylaggsltdvvtetcmdegqiaavcreclqaleflhsn
qvihrdiksdnillgmdgsvkltdfgfcpeqskrstmvgtpywmapevvtrkaygpkvdi
wslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnrclemdve
krgsakellqhqflkiakplssltpliaaakeat

Timeline for d4zjjd_:

• d4zjjd_ first appeared in SCOPe 2.05
  
• d4zjjd_ appears in SCOPe 2.07
  
• d4zjjd_ appears in the current release, SCOPe 2.08