SCOPe 2.08: Domain d4zjia_: 4zji A:

Lineage for d4zjia_ (4zji A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein pak1 [56146] (1 species)
   OPK group; PAK/STE20 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56147] (19 PDB entries)

8. Domain d4zjia_: 4zji A: [274409]
   automated match to d3q4za_
   complexed with 4oq, mg

Details for d4zjia_

PDB Entry: 4zji, 1.99 Å

PDB Description: pak1 in complex with 2-chloro-5-ethyl-8-fluoro-11-(4-methylpiperazin- 1-yl)-dibenzodiazepine

PDB Compounds: (A:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4zjia_:

Sequence, based on SEQRES records:

>d4zjia_ d.144.1.7 (A:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
leklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpkkelii
neilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcrec
lqaleflhsnqvihrdiksdnillgmdgsvkltdfgfcaqitpeqskrstmvgtpywmap
evvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsai
frdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatk

Sequence, based on observed residues (ATOM records):

>d4zjia_ d.144.1.7 (A:) pak1 {Human (Homo sapiens) [TaxId: 9606]}
leklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlkeliineilv
mrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcreclqale
flhsnqvihrdiksdnillgmdgsvkltdfgfcaqitptmvgtpywmapevvtrkaygpk
vdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnrclem
dvekrgsakellqhqflkiakplssltpliaaakeatk

Timeline for d4zjia_:

• d4zjia_ first appeared in SCOPe 2.05
  
• d4zjia_ appears in SCOPe 2.07