SCOPe 2.08: Domain d2muta1: 2mut A:220-297

Lineage for d2muta1 (2mut A:220-297)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.60: SAM domain-like [47768] (17 superfamilies)
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

4. Superfamily a.60.2: RuvA domain 2-like [47781] (7 families)
   duplication: contains two helix-hairpin-helix (HhH) motifs

5. Family a.60.2.5: Hef domain-like [140629] (4 proteins)
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain ((81795), that contains a single NMR structure of a monomeric truncated domain, 1kft)

6. Protein DNA excision repair protein ERCC-1 [140630] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [140631] (3 PDB entries)
   Uniprot P07992 219-296! Uniprot P07992 220-297

8. Domain d2muta1: 2mut A:220-297 [274219]
   Other proteins in same PDB: d2muta2, d2muta3, d2mutb1, d2mutb2
   automated match to d1z00a1
   mutant

Details for d2muta1

PDB Entry: 2mut

PDB Description: solution structure of the f231l mutant ercc1-xpf dimerization region

PDB Compounds: (A:) DNA excision repair protein ERCC-1

SCOPe Domain Sequences for d2muta1:

Sequence; same for both SEQRES and ATOM records:

>d2muta1 a.60.2.5 (A:220-297) DNA excision repair protein ERCC-1 {Human (Homo sapiens) [TaxId: 9606]}
adllmekleqdlvsrvteclttvksvnktdsqtllttfgsleqliaasredlalcpglgp
qkarrlfdvlhepflkvp

Timeline for d2muta1:

• d2muta1 first appeared in SCOPe 2.05, called d2muta_
  
• d2muta1 appears in SCOPe 2.07