SCOPe 2.07: Domain d4x25b_: 4x25 B:

Lineage for d4x25b_ (4x25 B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.110: Profilin-like [55769] (10 superfamilies)
   core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha

4. Superfamily d.110.1: Profilin (actin-binding protein) [55770] (2 families)
   alpha-beta(2)-alpha-beta(5)-alpha

5. Family d.110.1.1: Profilin (actin-binding protein) [55771] (2 proteins)
   automatically mapped to Pfam PF00235

6. Protein automated matches [190412] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187287] (9 PDB entries)

8. Domain d4x25b_: 4x25 B: [273785]
   automated match to d2vk3a_
   mutant

Details for d4x25b_

PDB Entry: 4x25, 2.23 Å

PDB Description: structural basis for mutation-induced destabilization of profilin 1 in als

PDB Compounds: (B:) Profilin-1

SCOPe Domain Sequences for d4x25b_:

Sequence, based on SEQRES records:

>d4x25b_ d.110.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfyv
ngltlggqkcsvirdsllqdgefsmdlrtkstggaptfnvtvtktdktlvlltgkegvhg
glinkkcyemashlrrsqy

Sequence, based on observed residues (ATOM records):

>d4x25b_ d.110.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agwnayidnlmdgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfyvn
gltlggqkcsvirdsllqdgefsmdlrttfnvtvtktdktlvlltgkegvhgglinkkcy
emashlrrsqy

Timeline for d4x25b_:

• d4x25b_ first appeared in SCOPe 2.05
  
• d4x25b_ appears in SCOPe 2.06
  
• d4x25b_ appears in the current release, SCOPe 2.08