SCOPe 2.08: Domain d4ymja1: 4ymj A:530-831

Lineage for d4ymja1 (4ymj A:530-831)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4ymja1: 4ymj A:530-831 [273536]
   Other proteins in same PDB: d4ymja2, d4ymjb2
   automated match to d4at5a_
   complexed with 4ej, cl, gol

Details for d4ymja1

PDB Entry: 4ymj, 2 Å

PDB Description: (r)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk inhibitors

PDB Compounds: (A:) NT-3 growth factor receptor

SCOPe Domain Sequences for d4ymja1:

Sequence, based on SEQRES records:

>d4ymja1 d.144.1.0 (A:530-831) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaarkdfqrea
elltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpdamilvdgqprqakg
elglsqmlhiasqiasgmvylasqhfvhrdlatrnclvganllvkigdfgmsrdvystdy
yrvgghtmlpirwmppesimyrkfttesdvwsfgvilweiftygkqpwfqlsntevieci
tqgrvlerprvcpkevydvmlgcwqrepqqrlnikeiykilhalgkat

Sequence, based on observed residues (ATOM records):

>d4ymja1 d.144.1.0 (A:530-831) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaarkdfqrea
elltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpgelglsqmlhiasqi
asgmvylasqhfvhrdlatrnclvganllvkigdfgdvystdyyrhtmlpirwmppesim
yrkfttesdvwsfgvilweiftygkqpwfqlsnteviecitqgrvlerprvcpkevydvm
lgcwqrepqqrlnikeiykilhalgkat

Timeline for d4ymja1:

• d4ymja1 first appeared in SCOPe 2.05, called d4ymja_
  
• d4ymja1 appears in SCOPe 2.07