Lineage for d4qoce_ (4qoc E:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2321461Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  4. 2321462Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families) (S)
    binds to the transactivation domain of human p53
  5. 2321463Family a.42.1.1: SWIB/MDM2 domain [47593] (5 protein domains)
    Pfam PF02201
  6. 2321470Protein MDM2 [47594] (2 species)
  7. 2321488Species Human (Homo sapiens) [TaxId:9606] [47596] (62 PDB entries)
  8. 2321535Domain d4qoce_: 4qoc E: [272376]
    automated match to d1t4ea_
    complexed with 35t

Details for d4qoce_

PDB Entry: 4qoc (more details), 1.7 Å

PDB Description: crystal structure of compound 16 bound to mdm2(17-111), {(3r,5r,6s)-5- (3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1s)-1-cyclopropyl-2- (pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid
PDB Compounds: (E:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d4qoce_:

Sequence, based on SEQRES records: (download)

>d4qoce_ a.42.1.1 (E:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d4qoce_ a.42.1.1 (E:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4qoce_:

Click to download the PDB-style file with coordinates for d4qoce_.
(The format of our PDB-style files is described here.)

Timeline for d4qoce_: