SCOPe 2.07: Domain d4zbfh1: 4zbf H:172-321

Lineage for d4zbfh1 (4zbf H:172-321)

1. Root: SCOPe 2.07

2. Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein automated matches [190236] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188722] (88 PDB entries)

8. Domain d4zbfh1: 4zbf H:172-321 [272110]
   Other proteins in same PDB: d4zbfa2, d4zbfb2, d4zbfc2, d4zbfd2, d4zbfe2, d4zbff2, d4zbfg2, d4zbfh2, d4zbfi2, d4zbfj2, d4zbfk2, d4zbfl2
   automated match to d2mhsa_
   complexed with 4m7

Details for d4zbfh1

PDB Entry: 4zbf, 2.2 Å

PDB Description: mcl-1 complexed with small molecules

PDB Compounds: (H:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4zbfh1:

Sequence; same for both SEQRES and ATOM records:

>d4zbfh1 f.1.4.1 (H:172-321) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

Timeline for d4zbfh1:

• d4zbfh1 first appeared in SCOPe 2.05, called d4zbfh_
  
• d4zbfh1 appears in SCOPe 2.06
  
• d4zbfh1 appears in the current release, SCOPe 2.08