SCOPe 2.08: Domain d4rwja1: 4rwj A:458-764

Lineage for d4rwja1 (4rwj A:458-764)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4rwja1: 4rwj A:458-764 [271707]
   Other proteins in same PDB: d4rwja2
   automated match to d4v04b_
   complexed with 66t

Details for d4rwja1

PDB Entry: 4rwj, 2.49 Å

PDB Description: crystal structure of fgfr1 (c488a, c584s) in complex with azd4547 (n- {3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5- dimethylpiperazin-1-yl]benzamide)

PDB Compounds: (A:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d4rwja1:

Sequence, based on SEQRES records:

>d4rwja1 d.144.1.7 (A:458-764) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnq

Sequence, based on observed residues (ATOM records):

>d4rwja1 d.144.1.7 (A:458-764) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykktngrlpvkwmapealfdriythqsdvwsfgvllweiftlgg
spypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldriv
altsnq

Timeline for d4rwja1:

• d4rwja1 first appeared in SCOPe 2.05, called d4rwja_
  
• d4rwja1 appears in SCOPe 2.07