SCOPe 2.05: Domain d4d2ra_: 4d2r A:

Lineage for d4d2ra_ (4d2r A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (17 PDB entries)

8. Domain d4d2ra_: 4d2r A: [271634]
   automated match to d1m7na_
   complexed with cl, dyk

Details for d4d2ra_

PDB Entry: 4d2r, 2.1 Å

PDB Description: human igf in complex with a dyrk1b inhibitor

PDB Compounds: (A:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d4d2ra_:

Sequence, based on SEQRES records:

>d4d2ra_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
dvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmrer
ieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemennpvl
appslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetd
yyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrf
vmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyysee
nk

Sequence, based on observed residues (ATOM records):

>d4d2ra_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
dvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmrer
ieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemennpvl
appslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetd
yyrkkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvm
egglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Timeline for d4d2ra_:

• d4d2ra_ is new in SCOPe 2.05-stable
  
• d4d2ra_ appears in SCOPe 2.06
  
• d4d2ra_ appears in the current release, SCOPe 2.08