SCOPe 2.06: Domain d4wdxb_: 4wdx B:

Lineage for d4wdxb_ (4wdx B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (43 PDB entries)
   Uniprot P42330

8. Domain d4wdxb_: 4wdx B: [271539]
   automated match to d1s1pa_
   complexed with nap, wdx

Details for d4wdxb_

PDB Entry: 4wdx, 1.64 Å

PDB Description: 17beta-hsd5 in complex with [4-(2-hydroxyethyl)piperidin-1-yl](5- methyl-1h-indol-2-yl)methanone

PDB Compounds: (B:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d4wdxb_:

Sequence, based on SEQRES records:

>d4wdxb_ c.1.7.1 (B:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsf

Sequence, based on observed residues (ATOM records):

>d4wdxb_ c.1.7.1 (B:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
lsptdgkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcn
qvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhk
rtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsd
sf

Timeline for d4wdxb_:

• d4wdxb_ first appeared in SCOPe 2.05
  
• d4wdxb_ appears in SCOPe 2.07
  
• d4wdxb_ appears in the current release, SCOPe 2.08