SCOPe 2.06: Domain d4wdxa_: 4wdx A:

Lineage for d4wdxa_ (4wdx A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (43 PDB entries)
   Uniprot P42330

8. Domain d4wdxa_: 4wdx A: [271538]
   automated match to d1s1pa_
   complexed with nap, wdx

Details for d4wdxa_

PDB Entry: 4wdx, 1.64 Å

PDB Description: 17beta-hsd5 in complex with [4-(2-hydroxyethyl)piperidin-1-yl](5- methyl-1h-indol-2-yl)methanone

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d4wdxa_:

Sequence, based on SEQRES records:

>d4wdxa_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsf

Sequence, based on observed residues (ATOM records):

>d4wdxa_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
lsptifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqvec
hpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrtpa
lialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsf

Timeline for d4wdxa_:

• d4wdxa_ first appeared in SCOPe 2.05
  
• d4wdxa_ appears in SCOPe 2.07
  
• d4wdxa_ appears in the current release, SCOPe 2.08