SCOPe 2.08: Domain d4rwlb_: 4rwl B:

Lineage for d4rwlb_ (4rwl B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4rwlb_: 4rwl B: [271518]
   automated match to d4v04b_
   complexed with 3zc, so4

Details for d4rwlb_

PDB Entry: 4rwl, 2.19 Å

PDB Description: crystal structure of fgfr1 (c488a, c584c) in complex with 6-(7-((1- aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1- naphthamide (e3810)

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d4rwlb_:

Sequence, based on SEQRES records:

>d4rwlb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnq

Sequence, based on observed residues (ATOM records):

>d4rwlb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppe
qlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglidyykkttn
grlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrm
dkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnq

Timeline for d4rwlb_:

• d4rwlb_ first appeared in SCOPe 2.05
  
• d4rwlb_ appears in SCOPe 2.07