SCOPe 2.05: Domain d4rn2a_: 4rn2 A:

Lineage for d4rn2a_ (4rn2 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (24 PDB entries)

8. Domain d4rn2a_: 4rn2 A: [271224]
   automated match to d4qa0a_
   complexed with k, l7g, zn

Details for d4rn2a_

PDB Entry: 4rn2, 2.39 Å

PDB Description: crystal structure of s39d hdac8 in complex with a largazole analogue.

PDB Compounds: (A:) Histone deacetylase 8

SCOPe Domain Sequences for d4rn2a_:

Sequence, based on SEQRES records:

>d4rn2a_ c.42.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfhtda
ylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckva
inwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftsk
vmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqa
fnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarc
wtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlk
hvv

Sequence, based on observed residues (ATOM records):

>d4rn2a_ c.42.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfhtda
ylqhlqkvsqsieygltegifdyaaaiggatitaaqclidgmckvainwsggwhhakkde
asgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhkfspgff
pgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvlqlgadt
iagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgvilgktls
seipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv

Timeline for d4rn2a_:

• d4rn2a_ is new in SCOPe 2.05-stable
  
• d4rn2a_ appears in SCOPe 2.06
  
• d4rn2a_ appears in the current release, SCOPe 2.08