SCOPe 2.06: Domain d4ptea_: 4pte A:

Lineage for d4ptea_ (4pte A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (43 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d4ptea_: 4pte A: [271207]
   automated match to d1j1bb_
   complexed with 2wf

Details for d4ptea_

PDB Entry: 4pte, 2.03 Å

PDB Description: structure of a carvoxamide compound (15) (n-[4-(isoquinolin-7-yl) pyridin-2-yl]cyclopropanecarboxamide) to gsk3b

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d4ptea_:

Sequence, based on SEQRES records:

>d4ptea_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpv
iyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvs
yicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgt
ptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleac
ahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilippha

Sequence, based on observed residues (ATOM records):

>d4ptea_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdfknre
lqimrkldhcnivrlryffyssdevylnlvldyvpetvyrvarhysrakqtlpviyvkly
myqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsry
yrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqi
remnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffd
elrdpnvklpngrdtpalfnfttqelssnpplatilippha

Timeline for d4ptea_:

• d4ptea_ first appeared in SCOPe 2.05
  
• d4ptea_ appears in SCOPe 2.07
  
• d4ptea_ appears in the current release, SCOPe 2.08