SCOPe 2.05: Domain d4xlia_: 4xli A:

Lineage for d4xlia_ (4xli A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d4xlia_: 4xli A: [271103]
   automated match to d3hmia_
   complexed with 1n1, zn

Details for d4xlia_

PDB Entry: 4xli, 2.5 Å

PDB Description: crystal structure of abl2/arg kinase in complex with dasatinib

PDB Compounds: (A:) Non-specific protein-tyrosine kinase

SCOPe Domain Sequences for d4xlia_:

Sequence, based on SEQRES records:

>d4xlia_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissame
ylekknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapesla
yntfsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelm
racwkwspadrpsfaethqafetmfhds

Sequence, based on observed residues (ATOM records):

>d4xlia_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkeveeflkeaavmkeikhp
nlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissameylek
knfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslayntf
siksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmracw
kwspadrpsfaethqafetmfhds

Timeline for d4xlia_:

• d4xlia_ is new in SCOPe 2.05-stable
  
• d4xlia_ appears in SCOPe 2.06
  
• d4xlia_ appears in the current release, SCOPe 2.08