SCOPe 2.06: Domain d3wsbc_: 3wsb C:

Lineage for d3wsbc_ (3wsb C:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.0: automated matches [196408] (1 protein)
   not a true family

6. Protein automated matches [196409] (37 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:353153] [256465] (6 PDB entries)

8. Domain d3wsbc_: 3wsb C: [271056]
   automated match to d3wccc_
   complexed with fps, rwz

Details for d3wsbc_

PDB Entry: 3wsb, 2.4 Å

PDB Description: the tuberculosis drug sq109 inhibits trypanosoma cruzi cell proliferation and acts synergistically with posaconazole

PDB Compounds: (C:) Farnesyltransferase, putative

SCOPe Domain Sequences for d3wsbc_:

Sequence; same for both SEQRES and ATOM records:

>d3wsbc_ a.128.1.0 (C:) automated matches {Trypanosoma cruzi [TaxId: 353153]}
dedlrfcydilqavsrsfavvimeldeemrdavcifylvlraldtveddmsipvefklre
lpkfhehlhdttwcmsgvgvgrerellerythvtraysrlgkayqdvisgicermangmc
dfltrkvetkadydlychyvaglvghgltllyvssgledvrladdltnanhmglflqktn
iirdfyedicevpprvfwpreiwekytddlhafkdelheakaveclnamvadalvhvphv
veylaslrdpsvfafsaipqvmamatlslvfnnkdvfhtkvkttrgatarifhystelqa
tlqmlktytlrlaarmnaqdacydriehlvndairameshq

Timeline for d3wsbc_:

• d3wsbc_ first appeared in SCOPe 2.05
  
• d3wsbc_ appears in SCOPe 2.07
  
• d3wsbc_ appears in the current release, SCOPe 2.08