SCOPe 2.05: Domain d4oewa_: 4oew A:

Lineage for d4oewa_ (4oew A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (26 PDB entries)

8. Domain d4oewa_: 4oew A: [270981]
   automated match to d3ly2a_
   complexed with 5io, mg, zn

Details for d4oewa_

PDB Entry: 4oew, 2.44 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4oewa_:

Sequence, based on SEQRES records:

>d4oewa_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
edcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d4oewa_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlalyikrr
geffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateffdqgkn
kipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d4oewa_:

• d4oewa_ is new in SCOPe 2.05-stable
  
• d4oewa_ appears in SCOPe 2.06
  
• d4oewa_ appears in the current release, SCOPe 2.08