SCOPe 2.05: Domain d4x8uh_: 4x8u H:

Lineage for d4x8uh_ (4x8u H:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (50 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d4x8uh_: 4x8u H: [270833]
   Other proteins in same PDB: d4x8ul_
   automated match to d1klih_
   complexed with 3zb, ca, gol, so4

Details for d4x8uh_

PDB Entry: 4x8u, 2.1 Å

PDB Description: factor viia in complex with the inhibitor 5-chloro-1h-indole-2- carboxylic acid

PDB Compounds: (H:) Factor VIIa (Heavy Chain)

SCOPe Domain Sequences for d4x8uh_:

Sequence, based on SEQRES records:

>d4x8uh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Sequence, based on observed residues (ATOM records):

>d4x8uh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrdspniteymfcagysdg
skdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsep
rpgvllrapfp

Timeline for d4x8uh_:

• d4x8uh_ is new in SCOPe 2.05-stable
  
• d4x8uh_ appears in SCOPe 2.06
  
• d4x8uh_ appears in the current release, SCOPe 2.08