SCOPe 2.05: Domain d4x1ic1: 4x1i C:1-245

Lineage for d4x1ic1 (4x1i C:1-245)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.32: Tubulin nucleotide-binding domain-like [52489] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

4. Superfamily c.32.1: Tubulin nucleotide-binding domain-like [52490] (2 families)
   automatically mapped to Pfam PF00091

5. Family c.32.1.1: Tubulin, GTPase domain [52491] (4 proteins)

6. Protein automated matches [226837] (6 species)
   not a true protein

7. Species Sheep (Ovis aries) [TaxId:9940] [224884] (11 PDB entries)

8. Domain d4x1ic1: 4x1i C:1-245 [270816]
   Other proteins in same PDB: d4x1ia2, d4x1ib2, d4x1ic2, d4x1id2, d4x1ie_
   automated match to d4ihja1
   complexed with 3wd, gdp, gtp, loc, mg

Details for d4x1ic1

PDB Entry: 4x1i, 3.11 Å

PDB Description: discovery of cytotoxic dolastatin 10 analogs with n-terminal modifications

PDB Compounds: (C:) Tubulin alpha chain

SCOPe Domain Sequences for d4x1ic1:

Sequence, based on SEQRES records:

>d4x1ic1 c.32.1.1 (C:1-245) automated matches {Sheep (Ovis aries) [TaxId: 9940]}
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrligqivssita
slrfd

Sequence, based on observed residues (ATOM records):

>d4x1ic1 c.32.1.1 (C:1-245) automated matches {Sheep (Ovis aries) [TaxId: 9940]}
mrecisihvgqagvqignacwelyclehgiqpdgqmpddsfntffsetgagkhvpravfv
dleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladq
ctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsi
ltthttlehsdcafmvdneaiydicrrnldierptytnlnrligqivssitaslrfd

Timeline for d4x1ic1:

• d4x1ic1 is new in SCOPe 2.05-stable
  
• d4x1ic1 appears in SCOPe 2.06
  
• d4x1ic1 appears in the current release, SCOPe 2.08