SCOPe 2.08: Domain d4q23a_: 4q23 A:

Lineage for d4q23a_ (4q23 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (85 PDB entries)

8. Domain d4q23a_: 4q23 A: [270391]
   automated match to d4demf_
   complexed with mg, ris, so4

Details for d4q23a_

PDB Entry: 4q23, 1.98 Å

PDB Description: the role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates

PDB Compounds: (A:) farnesyl pyrophosphate synthase

SCOPe Domain Sequences for d4q23a_:

Sequence, based on SEQRES records:

>d4q23a_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvvaf
relveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvglda
indanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrf
tekryksivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldl
fgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeel
dlpavflqyeedsyshimalieqyaaplppavflglarkiy

Sequence, based on observed residues (ATOM records):

>d4q23a_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vyaqekqdfvqhfsqivrvltghpeigdaiarlkevleynaiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekr
yksivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdp
svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
vflqyeedsyshimalieqyaaplppavflglarkiy

Timeline for d4q23a_:

• d4q23a_ first appeared in SCOPe 2.05
  
• d4q23a_ appears in SCOPe 2.07