Lineage for d4rx2a_ (4rx2 A:)

  1. Root: SCOPe 2.07
  2. 2618030Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)
  3. 2618349Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 2618350Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (4 families) (S)
  5. 2618351Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (19 proteins)
  6. 2618634Protein beta-Lactamase, class A [56606] (16 species)
  7. 2618665Species Escherichia coli, TEM-1 [TaxId:562] [56607] (62 PDB entries)
  8. 2618771Domain d4rx2a_: 4rx2 A: [269876]
    automated match to d1fqga_
    complexed with so4; mutant

Details for d4rx2a_

PDB Entry: 4rx2 (more details), 2.31 Å

PDB Description: a triple mutant in the omega-loop of tem-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis
PDB Compounds: (A:) Beta-lactamase TEM

SCOPe Domain Sequences for d4rx2a_:

Sequence, based on SEQRES records: (download)

>d4rx2a_ e.3.1.1 (A:) beta-Lactamase, class A {Escherichia coli, TEM-1 [TaxId: 562]}
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldryygelneaipnderdtttpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

Sequence, based on observed residues (ATOM records): (download)

>d4rx2a_ e.3.1.1 (A:) beta-Lactamase, class A {Escherichia coli, TEM-1 [TaxId: 562]}
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldryynderdtttpaamattlrklltgelltlasrqqlidwmea
dkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttgsqatmder
nrqiaeigaslikhw

SCOPe Domain Coordinates for d4rx2a_:

Click to download the PDB-style file with coordinates for d4rx2a_.
(The format of our PDB-style files is described here.)

Timeline for d4rx2a_: