SCOPe 2.08: Domain d4d46a_: 4d46 A:

Lineage for d4d46a_ (4d46 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein automated matches [190085] (59 species)
   not a true protein

7. Species Escherichia coli [TaxId:469008] [256724] (3 PDB entries)

8. Domain d4d46a_: 4d46 A: [269636]
   automated match to d1qg6a_
   complexed with j47, nad

Details for d4d46a_

PDB Entry: 4d46, 2 Å

PDB Description: crystal structure of e. coli fabi in complex with nad and 5- bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile

PDB Compounds: (A:) Enoyl-[acyl-carrier-protein] reductase [NADH]

SCOPe Domain Sequences for d4d46a_:

Sequence, based on SEQRES records:

>d4d46a_ c.2.1.2 (A:) automated matches {Escherichia coli [TaxId: 469008]}
gflsgkrilvtgvasklsiaygiaqamhregaelaftyqndklkgrveefaaqlgsdivl
qcdvaedasidtmfaelgkvwpkfdgfvhsigfapgdqldgdyvnavtregfkiahdiss
ysfvamakacrsmlnpgsalltlsylgaeraipnynvmglakasleanvrymanamgpeg
vrvnaisagpirtlaasgikdfrkmlahceavtpirrtvtiedvgnsaaflcsdlsagis
gevvhvdggfsiaamn

Sequence, based on observed residues (ATOM records):

>d4d46a_ c.2.1.2 (A:) automated matches {Escherichia coli [TaxId: 469008]}
gflsgkrilvtgvasklsiaygiaqamhregaelaftyqndklkgrveefaaqlgsdivl
qcdvaedasidtmfaelgkvwpkfdgfvhsigfapgdqldgdyvnavtregfkiahdiss
ysfvamakacrsmlnpgsalltlsylgaeraipnynvmglakasleanvrymanamgpeg
vrvnaisagpieavtpirrtvtiedvgnsaaflcsdlsagisgevvhvdggfsiaamn

Timeline for d4d46a_:

• d4d46a_ first appeared in SCOPe 2.05
  
• d4d46a_ appears in SCOPe 2.07